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Solidworks 2013 Flow Simulation Download 120 \/\/FREE\\\\

In the portal system, the pulsation characteristics of blood flow were not significant, so the numerical simulation in this study is simplified to steady simulation. In addition, the blood, as a preliminary study, was assumed to be incompressible, laminar, homogenous and Newtonian. The corresponding governing equations were as follows:

solidworks 2013 flow simulation download 120

In conclusion, the angulation of the SV and SMV was closely related to the formation of PVT. Numerical simulation analysis found that helical flow may change following the varying angulation of the SV and SMV. Therefore, angulation of the SV and SMV may help to earlier identify high-risk cohorts for future PVT earlier.

Patient-specific modelling in clinical studies requires a realistic simulation to be performed within a reasonable computational time. The aim of this study was to develop simple but realistic outflow boundary conditions for patient-specific blood flow simulation which can be used to clarify the distribution of the anticancer agent in intra-arterial chemotherapy for oral cancer.

In this study, the boundary conditions are expressed as a zero dimension (0D) resistance model of the peripheral vessel network based on the fractal characteristics of branching arteries combined with knowledge of the circulatory system and the energy minimization principle. This resistance model was applied to four patient-specific blood flow simulations at the region where the common carotid artery bifurcates into the internal and external carotid arteries.

The standard treatment for oral cancer is surgery, but radical surgery for advanced oral cancer often causes severe oral dysfunction, including speech and swallowing disorders. However, organ and function preservation can be maximized by adopting a multidisciplinary approach that combines radiotherapy and chemotherapy [1]. Selective or superselective intra-arterial chemotherapy, in particular, plays an important role in obviating the need for radical surgery. However, the side effects can be severe and the distribution of the anticancer agent to tumour-feeding arteries is unclear. Therefore, it is necessary to clarify the optimal dose of anticancer agent for each patient, and it is critical to obtain accurate information on flow distribution in each vessel for optimal drug delivery. Even though the final target of this study is to understand the distribution of the anticancer agent in the carotid artery area, including the branches of the external carotid artery (ECA) which act as feeding arteries for oral cancer, the present study focuses on patient-specific blood flow simulations in the area relevant for intra-arterial chemotherapy since anticancer agent flows are correlated with the blood flow due to their small concentration. Despite the recent progress of measurement methods, such as ultrasound-based methods, it is still difficult to obtain accurate information about the flow distribution in vessels, such as branches of the ECA, in deep soft tissues.

Because it is more convenient to use commercial software rather than custom-developed software in clinical studies, we have developed a simple boundary condition which can be implemented in commercial software. The model was applied to two patients in order to investigate the flow rate in branching arteries over a large number of cardiac cycles. A comparison between the numerical simulations and the ultrasound measurement data of the flow rates in the superficial temporal artery (STA) of the two patients was performed.

Before mesh generation for a simulation, the diameters of each artery immediately after branching were measured. In addition, each artery was cut off at a length 5 times the diameter in order to minimize the influences of both inflow and outflow boundary conditions on the flow distributions (Fig. 2a). Numerical analyses with the finite volume method (FVM) were performed using the general-purpose fluid dynamics software FLUENT (Ansys Inc, Canonsburg, PA). The meshes for the FVM were generated using ICEM-CFD software (Ansys Inc., Canonsburg, PA). The mesh consists of tetrahedral cells in the artery core and prismatic cells in the region near the artery wall, as shown in Fig. 2a, and the total number of cells was approximately 3,000,000. Due to this mesh configuration, the cells in the core region are regular while orthogonality was maintained near the wall. In order to resolve the boundary layer, it is necessary to create a fine mesh near the wall, but the calculation time results in increase. Because we suppose to use as a future clinical tool, the mesh requires to minimize within a range that does not affect the present analysis. Therefore, we adopted a tetra prism type mesh. In this paper, the first grid point from the wall was located within y+

We performed 3D blood flow simulations using three types of outflow boundary conditions as the alternative boundary conditions for patient-specific vessels models to be described later in detail: (1) zero-pressure outflow boundary conditions, (2) the pressure boundary conditions with the conventional 0D resistance model and (3) the pressure boundary conditions with the present 0D resistance model. In both 0D resistance models, a capillary with a radius of 12 μm or less was set to be the end of a branch. The conventional model used a constant λ (the ratio of the vessel length to its radius of 30) while λ in the present model varied depending on a size of a blood vessel diameter. Also, the terminal resistance in the present model was adjusted so that the terminal pressure became 30 mmHg, which is within the physiological range of the blood pressure. In two types of 0D resistance model, the flow rates acquired from the 3D analysis became the inflow boundary condtions for the 0D analysis while the pressure from the 0D analysis became the outflow boundary conditons for the 3D analysis. For the zero-pressure boundary condition, the pressures in all outlets were fixed at zero pressure in all outlets.

In order to achieve a realistic blood flow simulation, it is important to model appropriate physiological conditions, particularly boundary conditions. Even though the systemic arteries are compliant, vessels become stiffer with a smaller radius. Blood vessels are organized in a bifurcating tree in which the total cross-sectional area of the vessels expands from approximately 5 cm2 at the aortic root to approximately 400 cm2 at the arterioles [38]. This expansion in the total cross-sectional area occurs despite the decrease in diameter of individual vessels because the number of daughter vessels doubles at each bifurcation, as shown in Fig. 3. As the number of bifurcations increases, the flow resistance becomes higher and the pressure falls as blood flows through the arterial tree. In this paper, we adopt outflow boundary conditions based on a 0D resistance model to reflect the effects of the peripheral network on the 3D blood flow simulation; this allows us to conduct simulations using commercial software within a reasonable computation time. Since the diameter of the outlet in the 3D model varies, our 0D resistance model is divided into six groups (aorta, large arteries, main artery branches, terminal artery branches, arterioles and capillaries) depending on vessel diameter, as summarized in Fig. 4.

The outflow boundary conditions were developed as a 0D model to represent only the resistance of smaller arteries in the peripheral vessel network because this is easy to implement in the software used for the flow simulation. Since the peripheral network consists of relatively small blood vessels, the influence of resistance can be assumed to be more pronounced than that of compliance [42]. However, the elasticity of the arterioles and capillaries was reduced to reflect their properties.

To verify the simulation results, the blood velocities in the STA in each simulation were compared with those obtained from ultrasound measurements, as shown in Table 2. The mean error was defined as the average of the errors of the four models compared with the actual value obtained from ultrasound measurements, and the error value was calculated using the above-mentioned three types of boundary conditions. The mean error in the STA velocities in the simulation was 48.02 22.66 %, 5.32 4.52 % and 5.21 0.78 % for the zero-pressure outflow model, the conventional 0D resistance model and the present 0D resistance model, respectively (Fig. 8). The simulation based on the zero-pressure outflow boundary condition yielded the largest mean error of the three models, whereas both 0D resistance models provided small mean errors. However, the standard deviation of the present 0D resistance model was smaller than that of the conventional 0D resistance model, which implies that simulation based on the present model is more precise.

This study focused on head and neck haemodynamics for the treatment of oral cancer, especially in cases where intra-arterial chemotherapy is necessary. There have been few patient-specific blood flow simulations for oral cancer chemotherapy to date. Although Rhode et al. [56] previously reported the results of simulations of haemodynamic flow in head and neck cancer chemotherapy, where a patient-specific vessel model was created from CT images, branches of the ECA, such as the OA, MA and STA, were not modelled, and the peripheral vascular network was not considered. Our present 0D resistance model is clinically useful because it can provide an accurate estimation of the pressure and the flow distribution in vessels. The application of the present 0D resistance model as a boundary condition yields more realistic blood flow simulations the results of which can be used to achieve optimal tumour control with minimum accompanying side effects in oral cancer chemotherapy. In this paper, we consider a novel method for haemodynamic flow simulation applicable to intra-arterial chemotherapy for oral cancer.

We have presented some simple yet accurate outflow boundary conditions for conducting patient-specific blood simulations within a reasonable computation time for clinical applications. Since the region of interest in this study was the head and neck, the peripheral blood vessel network consists of mostly small blood vessels, which tend to be rigid. The outflow boundary conditions were designed based on the characteristics of the peripheral network by using the resistance of the blood vessel rather than the impedance, which combines compliance and resistance. To obtain an even more realistic simulation with the 0D model, the parameter λ was adjusted in accordance with anatomical knowledge.

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